1-palmitoyl-2-stearoyl-gpc (16:0/18:0) to 1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)*

Numerator Metabolite

Structure of 1-palmitoyl-2-stearoyl-gpc (16:0/18:0)
Metabolite Accession: GCST90200041
Name: 1-palmitoyl-2-stearoyl-gpc (16:0/18:0)
Hmdb Id: HMDB0007970
Super Pathway: NA
Sub Pathway: NA
Inchikey: PZNPLUBHRSSFHT

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)*
Metabolite Accession: GCST90200057
Name: 1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)*
Hmdb Id: HMDB0007996
Super Pathway: NA
Sub Pathway: NA
Inchikey: MPQGNHKVOVYEEN

Associated Genomic Regions

Region: rs964184

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.245
Position:
116648917
SE (Ratio):
0.026
Effect Allele:
G
Z-score (Ratio):
9.535
Reference Allele:
C
-log10(P):
-47.949
MAF:
0.131
Beta (Num):
0.153
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
-0.092
SE (Den):
0.022
No CNV overlap
rQTL cluster:
248
Reaction Distance:
NA
Closest Genes:
ZNF259 BUD13 APOA5 APOA4 APOC3

LLM Analysis

Numerator Metabolite Explanation:

Phosphatidylcholine biosynthesis

Denominator Metabolite Explanation:

Plasmalogen synthesis

Ratio Explanation:

This ratio may reflect the balance between phosphatidylcholine and plasmalogen synthesis. APOA1's role in lipid transport could influence the availability of substrates for these pathways.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic factors like APOA1 are linked to HDL and cholesterol metabolism.1[1], 2[2], 3[3], 4[4], 5[5], 6[6], 7[7] Alterations in the ratio of these specific lipids may contribute to dyslipidemia and the associated cardiovascular phenotypes like hypercholesterolemia and atherosclerosis.

Phenotype Driver:

Gene-centric:APOA1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data