1-palmitoyl-2-stearoyl-gpc (16:0/18:0) to 1,2-dilinoleoyl-gpe (18:2/18:2)*

Numerator Metabolite

Structure of 1-palmitoyl-2-stearoyl-gpc (16:0/18:0)
Metabolite Accession: GCST90200041
Name: 1-palmitoyl-2-stearoyl-gpc (16:0/18:0)
Hmdb Id: HMDB0007970
Super Pathway: NA
Sub Pathway: NA
Inchikey: PZNPLUBHRSSFHT

Denominator Metabolite

Structure of 1,2-dilinoleoyl-gpe (18:2/18:2)*
Metabolite Accession: GCST90200068
Name: 1,2-dilinoleoyl-gpe (18:2/18:2)*
Hmdb Id: HMDB0009093
Super Pathway: NA
Sub Pathway: NA
Inchikey: SSCDRSKJTAQNNB

Associated Genomic Regions

Region: rs174535

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.443
Position:
61551356
SE (Ratio):
0.022
Effect Allele:
C
Z-score (Ratio):
-19.695
Reference Allele:
T
-log10(P):
-197.159
MAF:
0.344
Beta (Num):
-0.214
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.229
SE (Den):
0.018
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Phospholipid biosynthesis, fatty acid metabolism.1[1]

Denominator Metabolite Explanation:

Phospholipid biosynthesis, fatty acid metabolism.1[1]

Ratio Explanation:

The ratio reflects FADS1/FADS2 desaturase activity, where lower levels suggest reduced conversion of linoleic acid to longer-chain fatty acids, impacting membrane composition and inflammation.3[1], 4[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced FADS1 activity, indicated by the metabolite ratio, is linked to altered lipid profiles, including cholesterol and triglycerides, which are risk factors for cholelithiasis and hypercholesterolemia.5[1], 6[2], 7[3]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data