1-palmitoyl-2-stearoyl-gpc (16:0/18:0) to 1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)*

Numerator Metabolite

Structure of 1-palmitoyl-2-stearoyl-gpc (16:0/18:0)
Metabolite Accession: GCST90200041
Name: 1-palmitoyl-2-stearoyl-gpc (16:0/18:0)
Hmdb Id: HMDB0007970
Super Pathway: NA
Sub Pathway: NA
Inchikey: PZNPLUBHRSSFHT

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)*
Metabolite Accession: GCST90200070
Name: 1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)*
Hmdb Id: HMDB0011207
Super Pathway: NA
Sub Pathway: NA
Inchikey: FZMYLOBGNYZPQO

Associated Genomic Regions

Region: rs964184

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.256
Position:
116648917
SE (Ratio):
0.027
Effect Allele:
G
Z-score (Ratio):
9.389
Reference Allele:
C
-log10(P):
-46.555
MAF:
0.131
Beta (Num):
0.153
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
-0.103
SE (Den):
0.022
No CNV overlap
rQTL cluster:
248
Reaction Distance:
NA
Closest Genes:
ZNF259 BUD13 APOA5 APOA4 APOC3

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism

Denominator Metabolite Explanation:

Ether lipid metabolism, Plasmalogen synthesis.4[1]

Ratio Explanation:

This ratio reflects the balance of diacyl-phosphatidylcholines to plasmalogens within circulating lipoproteins, which is influenced by the APOA1/C3/A4/A5 gene cluster's role in lipoprotein metabolism.3[1], 5[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in the APOA1/C3/A4/A5 cluster alter lipoprotein metabolism, impacting the composition of circulating lipids like phosphatidylcholines and plasmalogens.3[1], 6[2], 5[3], 7[4] This dyslipidemia is a primary contributor to atherosclerosis and related cardiovascular diseases such as myocardial infarction and hypercholesterolemia.6[5], 5[6]

Phenotype Driver:

Gene-centric:APOA5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data