1-palmitoyl-2-stearoyl-gpc (16:0/18:0) to 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*

Numerator Metabolite

Structure of 1-palmitoyl-2-stearoyl-gpc (16:0/18:0)
Metabolite Accession: GCST90200041
Name: 1-palmitoyl-2-stearoyl-gpc (16:0/18:0)
Hmdb Id: HMDB0007970
Super Pathway: NA
Sub Pathway: NA
Inchikey: PZNPLUBHRSSFHT

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*
Metabolite Accession: GCST90200075
Name: 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*
Hmdb Id: HMDB0011343
Super Pathway: NA
Sub Pathway: NA
Inchikey: LJVXDBWIBQQKFU

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.393
Position:
61581764
SE (Ratio):
0.021
Effect Allele:
C
Z-score (Ratio):
-18.347
Reference Allele:
T
-log10(P):
-171.447
MAF:
0.308
Beta (Num):
-0.232
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.161
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Phosphatidylcholine biosynthesis, glycerophospholipid metabolism.7[1], 8[2]

Denominator Metabolite Explanation:

Plasmalogen biosynthesis, glycerophospholipid metabolism.9[1], 10[2]

Ratio Explanation:

The ratio reflects the balance between phosphatidylcholine and plasmalogen synthesis. FADS enzymes influence the fatty acid pool for both, with plasmalogens being associated with FADS activity.11[1], 12[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters the production of specific fatty acids, influencing the composition of phospholipids like phosphatidylcholines and plasmalogens, which are linked to cardiometabolic health, inflammation, and various diseases.2[1], 3[2], 5[3], 11[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data