1-palmitoyl-2-stearoyl-gpc (16:0/18:0) to 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*

Numerator Metabolite

Structure of 1-palmitoyl-2-stearoyl-gpc (16:0/18:0)
Metabolite Accession: GCST90200041
Name: 1-palmitoyl-2-stearoyl-gpc (16:0/18:0)
Hmdb Id: HMDB0007970
Super Pathway: NA
Sub Pathway: NA
Inchikey: PZNPLUBHRSSFHT

Denominator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Metabolite Accession: GCST90200076
Name: 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Hmdb Id: HMDB0011376
Super Pathway: NA
Sub Pathway: NA
Inchikey: XVXISDREVDGQPX

Associated Genomic Regions

Region: rs174536

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.379
Position:
61551927
SE (Ratio):
0.019
Effect Allele:
C
Z-score (Ratio):
-19.953
Reference Allele:
A
-log10(P):
-202.287
MAF:
0.341
Beta (Num):
-0.214
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.164
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Phosphatidylcholine biosynthesis.3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Plasmalogen synthesis, Glycerophospholipid metabolism.5[1]

Ratio Explanation:

The ratio reflects the activity of FADS1, which is involved in the desaturation of fatty acids incorporated into both phosphatidylcholines and phosphatidylethanolamines.1[1], 6[2], 7[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS1 variants influence its expression and activity, altering the balance of pro-inflammatory and anti-inflammatory lipid mediators.6[1], 8[2] This dysregulation is linked to various phenotypes, including altered cholesterol levels and inflammatory conditions like follicular cysts, by affecting membrane composition and signaling pathways.9[3], 10[4], 11[5], 12[6], 13[7]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data