1-palmitoyl-2-stearoyl-gpc (16:0/18:0) to 1-stearoyl-2-oleoyl-gpi (18:0/18:1)*

Numerator Metabolite

Structure of 1-palmitoyl-2-stearoyl-gpc (16:0/18:0)
Metabolite Accession: GCST90200041
Name: 1-palmitoyl-2-stearoyl-gpc (16:0/18:0)
Hmdb Id: HMDB0007970
Super Pathway: NA
Sub Pathway: NA
Inchikey: PZNPLUBHRSSFHT

Denominator Metabolite

Metabolite Accession: GCST90200077
Name: 1-stearoyl-2-oleoyl-gpi (18:0/18:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.344
Position:
61588305
SE (Ratio):
0.017
Effect Allele:
G
Z-score (Ratio):
-20.402
Reference Allele:
A
-log10(P):
-211.355
MAF:
0.344
Beta (Num):
-0.213
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.131
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism

Denominator Metabolite Explanation:

Glycerophospholipid metabolism

Ratio Explanation:

The ratio reflects the balance between a saturated phosphatidylcholine and a monounsaturated phosphatidylinositol, which may be influenced by fatty acid desaturase (FADS2) activity.4[1], 5[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS genes, particularly FADS2, likely alters fatty acid desaturation, shifting the balance of saturated to unsaturated phospholipids.3[1], 4[2] This impacts lipoprotein metabolism and increases the risk for disorders like cholelithiasis and dyslipidemia, which show strong phenotype colocalization.

Phenotype Driver:

Gene-centric:FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data