1-palmitoyl-2-stearoyl-gpc (16:0/18:0) to 1-oleoyl-2-linoleoyl-gpe (18:1/18:2)*

Numerator Metabolite

Structure of 1-palmitoyl-2-stearoyl-gpc (16:0/18:0)
Metabolite Accession: GCST90200041
Name: 1-palmitoyl-2-stearoyl-gpc (16:0/18:0)
Hmdb Id: HMDB0007970
Super Pathway: NA
Sub Pathway: NA
Inchikey: PZNPLUBHRSSFHT

Denominator Metabolite

Metabolite Accession: GCST90200082
Name: 1-oleoyl-2-linoleoyl-gpe (18:1/18:2)*
Hmdb Id: HMDB0005349
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.607
Position:
61588305
SE (Ratio):
0.021
Effect Allele:
G
Z-score (Ratio):
-28.702
Reference Allele:
A
-log10(P):
-415.476
MAF:
0.344
Beta (Num):
-0.213
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.395
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism3[1], 4[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism5[1]

Ratio Explanation:

This ratio compares a saturated phosphatidylcholine to an unsaturated phosphatidylethanolamine, reflecting the balance between saturated and unsaturated fatty acid incorporation into different phospholipid backbones.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1/FADS2 gene variants alter desaturase activity, affecting the balance of saturated versus unsaturated fatty acids incorporated into phospholipids.1[1] This dysregulation impacts lipid profiles, contributing to hypercholesterolaemia and increasing the risk for associated inflammatory and cardiovascular phenotypes like phlebitis and pulmonary embolism.6[2], 7[3], 8[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data