1-palmitoyl-2-stearoyl-gpc (16:0/18:0) to 1-(1-enyl-palmitoyl)-2-palmitoyl-gpc (p-16:0/16:0)*

Numerator Metabolite

Structure of 1-palmitoyl-2-stearoyl-gpc (16:0/18:0)
Metabolite Accession: GCST90200041
Name: 1-palmitoyl-2-stearoyl-gpc (16:0/18:0)
Hmdb Id: HMDB0007970
Super Pathway: NA
Sub Pathway: NA
Inchikey: PZNPLUBHRSSFHT

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-palmitoyl-gpc (p-16:0/16:0)*
Metabolite Accession: GCST90200083
Name: 1-(1-enyl-palmitoyl)-2-palmitoyl-gpc (p-16:0/16:0)*
Hmdb Id: HMDB0011206
Super Pathway: NA
Sub Pathway: NA
Inchikey: PEWXKAOBUSBJLD

Associated Genomic Regions

Region: rs964184

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.244
Position:
116648917
SE (Ratio):
0.024
Effect Allele:
G
Z-score (Ratio):
9.967
Reference Allele:
C
-log10(P):
-52.202
MAF:
0.131
Beta (Num):
0.153
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
-0.091
SE (Den):
0.023
No CNV overlap
rQTL cluster:
248
Reaction Distance:
NA
Closest Genes:
ZNF259 BUD13 APOA5 APOA4 APOC3

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism

Denominator Metabolite Explanation:

Ether lipid metabolism

Ratio Explanation:

The ratio reflects the balance between diacyl-phosphatidylcholines and plasmalogens within lipoproteins; APOA5 variation likely alters lipoprotein composition and the relative abundance of these lipids.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Variants in APOA5 alter lipoprotein metabolism, reflected by the phosphatidylcholine to plasmalogen ratio. This resulting dyslipidemia is a known causal risk factor for cardiovascular phenotypes like coronary atherosclerosis and myocardial infarction.2[1], 5[2], 6[3]

Phenotype Driver:

Gene-centric:APOA5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data