1-palmitoyl-2-stearoyl-gpc (16:0/18:0) to 1-linoleoyl-2-linolenoyl-gpc (18:2/18:3)*

Numerator Metabolite

Structure of 1-palmitoyl-2-stearoyl-gpc (16:0/18:0)
Metabolite Accession: GCST90200041
Name: 1-palmitoyl-2-stearoyl-gpc (16:0/18:0)
Hmdb Id: HMDB0007970
Super Pathway: NA
Sub Pathway: NA
Inchikey: PZNPLUBHRSSFHT

Denominator Metabolite

Structure of 1-linoleoyl-2-linolenoyl-gpc (18:2/18:3)*
Metabolite Accession: GCST90200095
Name: 1-linoleoyl-2-linolenoyl-gpc (18:2/18:3)*
Hmdb Id: HMDB0008141
Super Pathway: NA
Sub Pathway: NA
Inchikey: HZGAVPNEGHQJID

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.447
Position:
61557803
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
-24.682
Reference Allele:
T
-log10(P):
-308.034
MAF:
0.346
Beta (Num):
-0.215
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.232
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Phospholipid biosynthesis, Fatty acid metabolism.3[1], 2[2]

Denominator Metabolite Explanation:

Phospholipid biosynthesis, Fatty acid metabolism.3[1], 4[2]

Ratio Explanation:

The ratio reflects the activity of FADS1, which is involved in the desaturation of fatty acids, influencing the balance between different polyunsaturated fatty acids.3[1], 5[2], 6[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1 activity alters the balance of omega-3 and omega-6 fatty acids, which can impact inflammatory processes and cholesterol metabolism, contributing to phenotypes like hypercholesterolemia, cholelithiasis, and inflammatory bowel disease.1[1], 7[2], 8[3], 9[4], 10[5]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data