1-palmitoyl-2-stearoyl-gpc (16:0/18:0) to dihomo-linolenoylcarnitine (c20:3n3 or 6)*

Numerator Metabolite

Structure of 1-palmitoyl-2-stearoyl-gpc (16:0/18:0)
Metabolite Accession: GCST90200041
Name: 1-palmitoyl-2-stearoyl-gpc (16:0/18:0)
Hmdb Id: HMDB0007970
Super Pathway: NA
Sub Pathway: NA
Inchikey: PZNPLUBHRSSFHT

Denominator Metabolite

Metabolite Accession: GCST90200139
Name: dihomo-linolenoylcarnitine (c20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
-0.387
Position:
61581764
SE (Ratio):
0.022
Effect Allele:
C
Z-score (Ratio):
-17.494
Reference Allele:
T
-log10(P):
-156.104
MAF:
0.308
Beta (Num):
-0.232
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.155
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Phospholipid Metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty Acid Metabolism.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio reflects FADS1 activity, where lower levels suggest reduced conversion of fatty acid precursors, impacting the balance of pro-inflammatory and anti-inflammatory lipids.4[1], 10[2], 11[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1 gene variants influence its expression and activity, altering the balance of fatty acids.12[1], 13[2] This dysregulation of lipid metabolism is linked to inflammatory skin conditions like seborrhoeic and infective dermatitis, and broader metabolic disorders.14[3], 12[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data