oleate/vaccenate (18:1) to adrenate (22:4n6)

Numerator Metabolite

Structure of oleate/vaccenate (18:1)
Metabolite Accession: GCST90200042
Name: oleate/vaccenate (18:1)
Hmdb Id: HMDB0003231,HMDB0000573,HMDB0240219,HMDB0000207
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWHZIFQPPBDJPM

Denominator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.190
Position:
61588305
SE (Ratio):
0.010
Effect Allele:
G
Z-score (Ratio):
18.523
Reference Allele:
A
-log10(P):
-174.705
MAF:
0.344
Beta (Num):
0.009
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.181
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis.3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid (PUFA) biosynthesis.6[1], 7[2], 8[3], 9[4]

Ratio Explanation:

The ratio reflects the efficiency of FADS-mediated conversion of oleate precursors to the long-chain polyunsaturated fatty acid adrenate, a key step in PUFA metabolism.1[1], 10[2], 6[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters polyunsaturated fatty acid (PUFA) synthesis, impacting inflammation and lipid metabolism.11[1], 12[2], 13[3] This dysregulation plausibly contributes to phenotypes like cholelithiasis, lipid disorders, and inflammatory conditions such as asthma and skin cysts.11[4], 12[5], 14[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data