oleate/vaccenate (18:1) to docosatrienoate (22:3n3)

Numerator Metabolite

Structure of oleate/vaccenate (18:1)
Metabolite Accession: GCST90200042
Name: oleate/vaccenate (18:1)
Hmdb Id: HMDB0003231,HMDB0000573,HMDB0240219,HMDB0000207
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWHZIFQPPBDJPM

Denominator Metabolite

Structure of docosatrienoate (22:3n3)
Metabolite Accession: GCST90199710
Name: docosatrienoate (22:3n3)
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Associated Genomic Regions

Region: rs61897793

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.277
Position:
61599347
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
-15.896
Reference Allele:
G
-log10(P):
-129.335
MAF:
0.181
Beta (Num):
0.002
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.279
SE (Den):
0.021
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 FADS3

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis.3[1], 4[2], 5[3], 6[4]

Denominator Metabolite Explanation:

Omega-3 fatty acid metabolism.7[1]

Ratio Explanation:

The ratio reflects the balance between monounsaturated (numerator) and omega-3 polyunsaturated (denominator) fatty acids, influenced by FADS2 activity in PUFA synthesis.8[1], 1[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS2 activity can decrease the synthesis of long-chain PUFAs like docosatrienoate (22:3n3), altering the fatty acid balance. This imbalance is linked to inflammatory conditions such as asthma and dermatitis, potentially through altered production of inflammatory mediators derived from these fatty acids.9[1], 10[2], 11[3], 12[4], 13[5], 14[6]

Phenotype Driver:

Gene-centric:FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data