oleate/vaccenate (18:1) to docosapentaenoate n3 DPA; 22:5n3

Numerator Metabolite

Structure of oleate/vaccenate (18:1)
Metabolite Accession: GCST90200042
Name: oleate/vaccenate (18:1)
Hmdb Id: HMDB0003231,HMDB0000573,HMDB0240219,HMDB0000207
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWHZIFQPPBDJPM

Denominator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.154
Position:
61581764
SE (Ratio):
0.010
Effect Allele:
C
Z-score (Ratio):
15.806
Reference Allele:
T
-log10(P):
-127.898
MAF:
0.308
Beta (Num):
0.013
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.141
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis7[1], 8[2], 9[3]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis10[1], 11[2], 12[3]

Ratio Explanation:

This ratio reflects the activity of FADS enzymes; a higher ratio suggests reduced FADS activity, leading to an accumulation of precursor fatty acids (oleate/vaccenate) and decreased synthesis of downstream products like DPA.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity alters the fatty acid profile, impacting cell membrane composition and inflammatory pathways.1[1], 13[2] This dysregulation in fatty acid metabolism is linked to follicular cyst formation, potentially by disrupting normal follicle development.13[3], 14[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data