oleate/vaccenate (18:1) to stearidonate (18:4n3)

Numerator Metabolite

Structure of oleate/vaccenate (18:1)
Metabolite Accession: GCST90200042
Name: oleate/vaccenate (18:1)
Hmdb Id: HMDB0003231,HMDB0000573,HMDB0240219,HMDB0000207
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWHZIFQPPBDJPM

Denominator Metabolite

Structure of stearidonate (18:4n3)
Metabolite Accession: GCST90199721
Name: stearidonate (18:4n3)
Hmdb Id: HMDB0006547
Super Pathway: NA
Sub Pathway: NA
Inchikey: JIWBIWFOSCKQMA

Associated Genomic Regions

Region: rs174566

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.129
Position:
61592362
SE (Ratio):
0.012
Effect Allele:
G
Z-score (Ratio):
10.932
Reference Allele:
A
-log10(P):
-62.382
MAF:
0.345
Beta (Num):
0.012
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.118
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis5[1], 6[2]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid metabolism7[1], 8[2], 9[3]

Ratio Explanation:

The ratio reflects the balance between oleate/vaccenate and the product of FADS2-mediated desaturation of alpha-linolenic acid, indicating FADS2 enzymatic activity.10[1], 7[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS2 activity, indicated by the elevated ratio, is associated with altered lipid profiles, including lower HDL and higher triglycerides, and an increased risk for cholelithiasis and type 2 diabetes.11[1], 12[2], 13[3], 14[4], 15[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data