oleate/vaccenate (18:1) to docosapentaenoate (n6 dpa; 22:5n6)

Numerator Metabolite

Structure of oleate/vaccenate (18:1)
Metabolite Accession: GCST90200042
Name: oleate/vaccenate (18:1)
Hmdb Id: HMDB0003231,HMDB0000573,HMDB0240219,HMDB0000207
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWHZIFQPPBDJPM

Denominator Metabolite

Structure of docosapentaenoate (n6 dpa; 22:5n6)
Metabolite Accession: GCST90199796
Name: docosapentaenoate (n6 dpa; 22:5n6)
Hmdb Id: HMDB0001976
Super Pathway: NA
Sub Pathway: NA
Inchikey: AVKOENOBFIYBSA

Associated Genomic Regions

Region: rs174536

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.122
Position:
61551927
SE (Ratio):
0.013
Effect Allele:
C
Z-score (Ratio):
9.667
Reference Allele:
A
-log10(P):
-49.229
MAF:
0.341
Beta (Num):
0.009
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.113
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis4[1]

Denominator Metabolite Explanation:

Fatty acid biosynthesis5[1], 6[2]

Ratio Explanation:

The ratio reflects the activity of the FADS-mediated desaturation pathway, where higher values suggest increased production of precursors relative to long-chain polyunsaturated fatty acids.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in the FADS cluster, particularly affecting FADS2 expression and function, alter the balance of fatty acids, which is associated with a range of metabolic and inflammatory phenotypes including cholelithiasis, type 2 diabetes, and disorders of lipoprotein metabolism.1[1], 7[2], 8[3], 9[4], 10[5]

Phenotype Driver:

Gene-centric:FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data