oleate/vaccenate (18:1) to hexadecanedioate (c16-dc)

Numerator Metabolite

Structure of oleate/vaccenate (18:1)
Metabolite Accession: GCST90200042
Name: oleate/vaccenate (18:1)
Hmdb Id: HMDB0003231,HMDB0000573,HMDB0240219,HMDB0000207
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWHZIFQPPBDJPM

Denominator Metabolite

Structure of hexadecanedioate (c16-dc)
Metabolite Accession: GCST90199807
Name: hexadecanedioate (c16-dc)
Hmdb Id: HMDB0000672
Super Pathway: NA
Sub Pathway: NA
Inchikey: QQHJDPROMQRDLA

Associated Genomic Regions

Region: rs77420750

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
0.143
Position:
15979744
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
8.700
Reference Allele:
C
-log10(P):
-40.247
MAF:
0.297
Beta (Num):
0.048
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.095
SE (Den):
0.016
No CNV overlap
rQTL cluster:
10
Reaction Distance:
NA
Closest Genes:
CYP4F2 CYP4F11 OR10H1 OR10H5 OR10H4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis, elongation, and desaturation pathways.7[1], 8[2], 9[3]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation.10[1], 11[2]

Ratio Explanation:

The ratio of oleate/vaccenate to hexadecanedioate may reflect the balance between fatty acid synthesis/elongation and omega-oxidation, a process in which CYP4F2 is involved.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The CYP4F2 missense variant is associated with reduced enzyme activity, potentially leading to altered fatty acid metabolism.1[1], 2[2] This alteration, reflected in the oleate/hexadecanedioate ratio, is linked to coronary atherosclerosis and ischaemic heart disease, conditions also associated with CYP4F2 polymorphisms.12[3], 13[4], 14[5] Altered bilirubin transport by SLCO1B1 may also contribute.15[6], 16[7], 17[8]

Phenotype Driver:

Gene-centric:CYP4F2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data