oleate/vaccenate (18:1) to dihomo-linolenate (20:3n3 or n6)

Numerator Metabolite

Structure of oleate/vaccenate (18:1)
Metabolite Accession: GCST90200042
Name: oleate/vaccenate (18:1)
Hmdb Id: HMDB0003231,HMDB0000573,HMDB0240219,HMDB0000207
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWHZIFQPPBDJPM

Denominator Metabolite

Structure of dihomo-linolenate (20:3n3 or n6)
Metabolite Accession: GCST90199820
Name: dihomo-linolenate (20:3n3 or n6)
Hmdb Id: HMDB0002925
Super Pathway: NA
Sub Pathway: NA
Inchikey: AHANXAKGNAKFSK

Associated Genomic Regions

Region: rs61897793

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.145
Position:
61599347
SE (Ratio):
0.012
Effect Allele:
A
Z-score (Ratio):
-11.954
Reference Allele:
G
-log10(P):
-74.162
MAF:
0.181
Beta (Num):
0.002
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.147
SE (Den):
0.019
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 FADS3

Region: rs12928099

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Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
-0.091
Position:
15150505
SE (Ratio):
0.010
Effect Allele:
A
Z-score (Ratio):
-8.837
Reference Allele:
C
-log10(P):
-41.466
MAF:
0.291
Beta (Num):
0.009
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.100
SE (Den):
0.016
No CNV overlap
rQTL cluster:
34
Reaction Distance:
NA
Closest Genes:
PDXDC1 NTAN1 RRN3 NPIPA1 NOMO1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio reflects the activity of FADS2, which is involved in the desaturation of oleate and the synthesis pathway leading to dihomo-linolenate.10[1], 11[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered FADS2 activity, reflected by the oleate to dihomo-linolenate ratio, impacts the balance of fatty acids, which has been linked to inflammatory skin conditions like seborrhoeic dermatitis and systemic effects on cholesterol and blood cell counts.12[1], 13[2], 14[3], 15[4]

Phenotype Driver:

Gene-centric:FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data