oleate/vaccenate (18:1) to hexanoylglutamine

Numerator Metabolite

Structure of oleate/vaccenate (18:1)
Metabolite Accession: GCST90200042
Name: oleate/vaccenate (18:1)
Hmdb Id: HMDB0003231,HMDB0000573,HMDB0240219,HMDB0000207
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWHZIFQPPBDJPM

Denominator Metabolite

Structure of hexanoylglutamine
Metabolite Accession: GCST90199833
Name: hexanoylglutamine
Hmdb Id: HMDB0242182
Super Pathway: NA
Sub Pathway: NA
Inchikey: NONGMLDQXRDGIT

Associated Genomic Regions

Region: rs1177442

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.321
Position:
25809069
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
22.447
Reference Allele:
G
-log10(P):
-255.272
MAF:
0.444
Beta (Num):
0.003
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.318
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis9[1], 10[2], 11[3], 12[4]

Denominator Metabolite Explanation:

Fatty acid metabolism (acyl glutamine)13[1], 14[2]

Ratio Explanation:

An elevated ratio may indicate decreased ACADM activity, leading to the accumulation of upstream fatty acids like oleate and forcing alternative metabolism through hexanoylglutamine.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced ACADM function, indicated by the elevated ratio, can lead to accumulation of medium-chain fatty acids. This disruption of fatty acid metabolism is linked to altered red blood cell characteristics (MCHC, MCH, Ht, Hb, MCV), and changes in renal function markers (uric acid, creatinine) and glucose metabolism (HbA1c).5[1], 15[2], 16[3], 17[4], 18[5]

Phenotype Driver:

Gene-centric:ACADM

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data