oleate/vaccenate (18:1) to n-oleoyltaurine

Numerator Metabolite

Structure of oleate/vaccenate (18:1)
Metabolite Accession: GCST90200042
Name: oleate/vaccenate (18:1)
Hmdb Id: HMDB0003231,HMDB0000573,HMDB0240219,HMDB0000207
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWHZIFQPPBDJPM

Denominator Metabolite

Structure of n-oleoyltaurine
Metabolite Accession: GCST90199912
Name: n-oleoyltaurine
Hmdb Id: HMDB0242113
Super Pathway: NA
Sub Pathway: NA
Inchikey: KOGRJTUIKPMZEJ

Associated Genomic Regions

Region: rs324420

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.272
Position:
46870761
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
-16.438
Reference Allele:
C
-log10(P):
-138.138
MAF:
0.209
Beta (Num):
-0.033
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
0.239
SE (Den):
0.019
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis; fatty acid beta-oxidation.7[1], 8[2], 9[3], 10[4]

Denominator Metabolite Explanation:

Fatty acid amide metabolism.11[1], 12[2], 13[3]

Ratio Explanation:

The ratio reflects FAAH activity; decreased FAAH function leads to less degradation of N-oleoyltaurine, increasing its level relative to its breakdown product, oleate.

Ratio Evidence:

canonical reaction catalyzed by the enzyme

Gene Ratio Phenotype Relationship:

No phenotype link was provided in the input data, so a causal relationship between the genetic factor, metabolic ratio, and any phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data