oleate/vaccenate (18:1) to tetradecadienoate (14:2)*

Numerator Metabolite

Structure of oleate/vaccenate (18:1)
Metabolite Accession: GCST90200042
Name: oleate/vaccenate (18:1)
Hmdb Id: HMDB0003231,HMDB0000573,HMDB0240219,HMDB0000207
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWHZIFQPPBDJPM

Denominator Metabolite

Structure of tetradecadienoate (14:2)*
Metabolite Accession: GCST90200187
Name: tetradecadienoate (14:2)*
Hmdb Id: HMDB0000560
Super Pathway: NA
Sub Pathway: NA
Inchikey: HXHZGHRLVRFQDR

Associated Genomic Regions

Region: rs28415528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.150
Position:
151879761
SE (Ratio):
0.011
Effect Allele:
A
Z-score (Ratio):
13.664
Reference Allele:
G
-log10(P):
-96.195
MAF:
0.318
Beta (Num):
0.026
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.123
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis, fatty acid metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis, fatty acid desaturation.5[1], 6[2]

Ratio Explanation:

This ratio likely reflects the balance of fatty acid pools, influenced by THEM4's hydrolysis of C14 to C18 acyl-CoA substrates, precursors for both metabolites.2[1], 7[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

No phenotype was provided, so a causal link between the THEM4-regulated oleate/tetradecadienoate ratio and a clinical outcome cannot be established from the given data.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data