oleate/vaccenate (18:1) to palmitoleate (16:1n7)

Numerator Metabolite

Structure of oleate/vaccenate (18:1)
Metabolite Accession: GCST90200042
Name: oleate/vaccenate (18:1)
Hmdb Id: HMDB0003231,HMDB0000573,HMDB0240219,HMDB0000207
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWHZIFQPPBDJPM

Denominator Metabolite

Structure of palmitoleate (16:1n7)
Metabolite Accession: GCST90200388
Name: palmitoleate (16:1n7)
Hmdb Id: HMDB0003229
Super Pathway: NA
Sub Pathway: NA
Inchikey: SECPZKHBENQXJG

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.115
Position:
102075479
SE (Ratio):
0.010
Effect Allele:
A
Z-score (Ratio):
11.921
Reference Allele:
G
-log10(P):
-73.760
MAF:
0.176
Beta (Num):
-0.013
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.128
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis/desaturation.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid biosynthesis/desaturation.7[1], 8[2], 9[3]

Ratio Explanation:

This ratio reflects the activity of Stearoyl-CoA Desaturase (SCD), which synthesizes both oleate and palmitoleate from their saturated fatty acid precursors.1[1], 2[2], 3[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in SCD alters its activity, impacting the oleate/palmitoleate ratio.10[1], 11[2] This dysregulation of fatty acid metabolism is linked to lipoprotein disorders, hypercholesterolemia, and an increased risk of coronary atherosclerosis and myocardial infarction, which are observed phenotypes.12[3], 13[4], 14[5], 15[6]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data