oleate/vaccenate (18:1) to palmitate (16:0)

Numerator Metabolite

Structure of oleate/vaccenate (18:1)
Metabolite Accession: GCST90200042
Name: oleate/vaccenate (18:1)
Hmdb Id: HMDB0003231,HMDB0000573,HMDB0240219,HMDB0000207
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWHZIFQPPBDJPM

Denominator Metabolite

Structure of palmitate (16:0)
Metabolite Accession: GCST90200397
Name: palmitate (16:0)
Hmdb Id: HMDB0000220
Super Pathway: NA
Sub Pathway: NA
Inchikey: IPCSVZSSVZVIGE

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.059
Position:
102075479
SE (Ratio):
0.008
Effect Allele:
A
Z-score (Ratio):
-7.872
Reference Allele:
G
-log10(P):
-33.287
MAF:
0.176
Beta (Num):
-0.013
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
0.046
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
4.0
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis.3[1]

Denominator Metabolite Explanation:

Fatty acid biosynthesis.4[1]

Ratio Explanation:

The ratio of oleate/vaccenate to palmitate indicates Stearoyl-CoA Desaturase (SCD) activity, reflecting the conversion rate of saturated to monounsaturated fatty acids.2[1], 5[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered SCD activity, reflected by the oleate/palmitate ratio, impacts lipid composition and metabolism.2[1] This dysfunction is associated with an increased risk of dyslipidemia and cardiovascular diseases like coronary atherosclerosis and myocardial infarction, which are listed as associated FinnGen traits.6[2]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data