1-palmitoyl-2-docosahexaenoyl-gpc (16:0/22:6) to docosapentaenoate n3 DPA; 22:5n3

Numerator Metabolite

Structure of 1-palmitoyl-2-docosahexaenoyl-gpc (16:0/22:6)
Metabolite Accession: GCST90200043
Name: 1-palmitoyl-2-docosahexaenoyl-gpc (16:0/22:6)
Hmdb Id: HMDB0007991
Super Pathway: NA
Sub Pathway: NA
Inchikey: IESVDEZGAHUQJU

Denominator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Associated Genomic Regions

Region: rs3798707

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.203
Position:
10991935
SE (Ratio):
0.018
Effect Allele:
T
Z-score (Ratio):
-11.410
Reference Allele:
C
-log10(P):
-67.762
MAF:
0.430
Beta (Num):
-0.149
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.053
SE (Den):
0.015
No CNV overlap
rQTL cluster:
112
Reaction Distance:
NA
Closest Genes:
ELOVL2 SYCP2L RP11-637O19.3 SMIM13 GCM2

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, PUFA biosynthesis.5[1], 6[2]

Denominator Metabolite Explanation:

Omega-3 fatty acid biosynthesis.1[1], 2[2]

Ratio Explanation:

The ratio reflects the ELOVL2-mediated elongation of DPA (22:5n3) to form DHA (22:6), which is then incorporated into phosphatidylcholine.2[1], 4[2], 7[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

No phenotype was provided, so no causal link between the ELOVL2 gene, the metabolic ratio, and a phenotype can be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data