1-palmitoyl-2-docosahexaenoyl-gpc (16:0/22:6) to dihomo-linolenate (20:3n3 or n6)

Numerator Metabolite

Structure of 1-palmitoyl-2-docosahexaenoyl-gpc (16:0/22:6)
Metabolite Accession: GCST90200043
Name: 1-palmitoyl-2-docosahexaenoyl-gpc (16:0/22:6)
Hmdb Id: HMDB0007991
Super Pathway: NA
Sub Pathway: NA
Inchikey: IESVDEZGAHUQJU

Denominator Metabolite

Structure of dihomo-linolenate (20:3n3 or n6)
Metabolite Accession: GCST90199820
Name: dihomo-linolenate (20:3n3 or n6)
Hmdb Id: HMDB0002925
Super Pathway: NA
Sub Pathway: NA
Inchikey: AHANXAKGNAKFSK

Associated Genomic Regions

Region: rs174549

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.261
Position:
61571382
SE (Ratio):
0.021
Effect Allele:
A
Z-score (Ratio):
-12.188
Reference Allele:
G
-log10(P):
-77.006
MAF:
0.303
Beta (Num):
-0.167
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.093
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Phosphatidylcholine biosynthesis5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Fatty acid biosynthesis8[1], 9[2], 10[3]

Ratio Explanation:

This ratio reflects the activity of FADS1 and FADS2 enzymes; lower activity leads to an accumulation of precursors like dihomo-linolenate and reduced levels of products like DHA-containing phospholipids.1[1], 2[2], 11[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in the FADS gene cluster (FADS1/FADS2) are associated with altered fatty acid metabolism, influencing plasma lipid levels (cholesterol, triglycerides) and inflammation, which are risk factors for cholelithiasis and cardiovascular diseases.12[1], 13[2], 14[3], 15[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data