1-palmitoyl-2-docosahexaenoyl-gpc (16:0/22:6) to 1-linoleoyl-gpi (18:2)*

Numerator Metabolite

Structure of 1-palmitoyl-2-docosahexaenoyl-gpc (16:0/22:6)
Metabolite Accession: GCST90200043
Name: 1-palmitoyl-2-docosahexaenoyl-gpc (16:0/22:6)
Hmdb Id: HMDB0007991
Super Pathway: NA
Sub Pathway: NA
Inchikey: IESVDEZGAHUQJU

Denominator Metabolite

Structure of 1-linoleoyl-gpi (18:2)*
Metabolite Accession: GCST90199821
Name: 1-linoleoyl-gpi (18:2)*
Hmdb Id: HMDB0240597
Super Pathway: NA
Sub Pathway: NA
Inchikey: SAHCQBPGXQFTRA

Associated Genomic Regions

Region: rs174547

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.331
Position:
61570783
SE (Ratio):
0.023
Effect Allele:
C
Z-score (Ratio):
-14.526
Reference Allele:
T
-log10(P):
-108.404
MAF:
0.338
Beta (Num):
-0.166
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.165
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Phosphatidylcholine Biosynthesis, Phospholipid Metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Phosphatidylinositol Metabolism, Glycerophospholipid Metabolism.5[1], 6[2]

Ratio Explanation:

This ratio reflects the activity of FADS1/FADS2 enzymes, which are involved in the synthesis of docosahexaenoic acid (22:6) from precursors like linoleic acid (18:2).1[1], 7[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in the FADS gene cluster alter the efficiency of polyunsaturated fatty acid synthesis, affecting the balance of pro-inflammatory and anti-inflammatory molecules.8[1], 9[2] This imbalance is associated with a wide range of inflammatory and metabolic disorders, including IBD, asthma, and hypercholesterolemia.10[3], 11[4], 12[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data