1-palmitoyl-2-docosahexaenoyl-gpc (16:0/22:6) to 1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)*

Numerator Metabolite

Structure of 1-palmitoyl-2-docosahexaenoyl-gpc (16:0/22:6)
Metabolite Accession: GCST90200043
Name: 1-palmitoyl-2-docosahexaenoyl-gpc (16:0/22:6)
Hmdb Id: HMDB0007991
Super Pathway: NA
Sub Pathway: NA
Inchikey: IESVDEZGAHUQJU

Denominator Metabolite

Structure of 1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)*
Metabolite Accession: GCST90200073
Name: 1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)*
Hmdb Id: HMDB0008147
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZZSZQATYGVHNLZ

Associated Genomic Regions

Region: rs3734398

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.226
Position:
10982973
SE (Ratio):
0.020
Effect Allele:
C
Z-score (Ratio):
-11.552
Reference Allele:
T
-log10(P):
-69.403
MAF:
0.425
Beta (Num):
-0.150
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.076
SE (Den):
0.015
No CNV overlap
rQTL cluster:
112
Reaction Distance:
NA
Closest Genes:
ELOVL2 SYCP2L RP11-637O19.3 GCM2 SMIM13

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, PUFA biosynthesis.4[1], 5[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, PUFA biosynthesis.6[1], 7[2]

Ratio Explanation:

The ratio reflects the enzymatic activity of ELOVL2, which is essential for synthesizing the DHA (22:6) in the numerator from PUFA precursors.8[1], 9[2], 10[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data