1-palmitoyl-2-docosahexaenoyl-gpc (16:0/22:6) to 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*

Numerator Metabolite

Structure of 1-palmitoyl-2-docosahexaenoyl-gpc (16:0/22:6)
Metabolite Accession: GCST90200043
Name: 1-palmitoyl-2-docosahexaenoyl-gpc (16:0/22:6)
Hmdb Id: HMDB0007991
Super Pathway: NA
Sub Pathway: NA
Inchikey: IESVDEZGAHUQJU

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*
Metabolite Accession: GCST90200075
Name: 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*
Hmdb Id: HMDB0011343
Super Pathway: NA
Sub Pathway: NA
Inchikey: LJVXDBWIBQQKFU

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.337
Position:
61569830
SE (Ratio):
0.024
Effect Allele:
T
Z-score (Ratio):
-13.877
Reference Allele:
C
-log10(P):
-99.146
MAF:
0.339
Beta (Num):
-0.166
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.171
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Phosphatidylcholine biosynthesis4[1], 5[2]

Denominator Metabolite Explanation:

Plasmalogen biosynthesis, Glycerophospholipid metabolism6[1], 7[2], 8[3]

Ratio Explanation:

This ratio reflects FADS1/FADS2 activity, comparing a phosphatidylcholine with DHA (omega-3) to a plasmalogen with linoleic acid (omega-6), both influenced by FADS desaturation.1[1], 9[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS1/FADS2 variants alter PUFA metabolism, affecting the balance of omega-3 and omega-6 derived lipids.9[1], 2[2] This dysregulation influences inflammatory and lipid pathways, plausibly increasing risk for associated phenotypes like asthma, hypercholesterolemia, and cholelithiasis.10[3], 11[4], 12[5], 13[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data