1-palmitoyl-2-docosahexaenoyl-gpc (16:0/22:6) to 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*

Numerator Metabolite

Structure of 1-palmitoyl-2-docosahexaenoyl-gpc (16:0/22:6)
Metabolite Accession: GCST90200043
Name: 1-palmitoyl-2-docosahexaenoyl-gpc (16:0/22:6)
Hmdb Id: HMDB0007991
Super Pathway: NA
Sub Pathway: NA
Inchikey: IESVDEZGAHUQJU

Denominator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Metabolite Accession: GCST90200080
Name: 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Hmdb Id: HMDB0009783
Super Pathway: NA
Sub Pathway: NA
Inchikey: PDLAMJKMOKWLAJ

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.269
Position:
61588305
SE (Ratio):
0.021
Effect Allele:
G
Z-score (Ratio):
-12.553
Reference Allele:
A
-log10(P):
-81.545
MAF:
0.343
Beta (Num):
-0.163
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.106
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

PUFA biosynthesis, Glycerophospholipid metabolism

Denominator Metabolite Explanation:

Fatty acid biosynthesis, Glycerophospholipid metabolism

Ratio Explanation:

This ratio reflects FADS enzyme activity, comparing a phosphatidylcholine with a highly unsaturated fatty acid (22:6) to a phosphatidylinositol with a monounsaturated one (18:1).4[1], 5[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters polyunsaturated fatty acid synthesis, impacting the balance of pro/anti-inflammatory lipids.1[1], 3[2], 6[3] This dysregulation of lipid metabolism and inflammation likely contributes to the observed risk for cholelithiasis, dyslipidemia, and asthma, which are strongly associated with these genetic loci.5[4], 7[5], 8[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data