1-(1-enyl-stearoyl)-2-oleoyl-gpe (p-18:0/18:1) to 1-(1-enyl-stearoyl)-gpe (p-18:0)*

Numerator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-oleoyl-gpe (p-18:0/18:1)
Metabolite Accession: GCST90200044
Name: 1-(1-enyl-stearoyl)-2-oleoyl-gpe (p-18:0/18:1)
Hmdb Id: HMDB0011375
Super Pathway: NA
Sub Pathway: NA
Inchikey: XVYPOHCSLJZFED

Denominator Metabolite

Metabolite Accession: GCST90199910
Name: 1-(1-enyl-stearoyl)-gpe (p-18:0)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.157
Position:
61581764
SE (Ratio):
0.017
Effect Allele:
C
Z-score (Ratio):
9.303
Reference Allele:
T
-log10(P):
-45.741
MAF:
0.308
Beta (Num):
0.032
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.125
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Ether lipid/Glycerophospholipid metabolism.3[1]

Denominator Metabolite Explanation:

Ether lipid/Glycerophospholipid metabolism.4[1]

Ratio Explanation:

This ratio indicates the acylation of a lysoplasmalogen to a plasmalogen, a process influenced by the availability of fatty acids regulated by FADS1.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1 gene variants impact fatty acid profiles, influencing susceptibility to hypercholesterolemia, asthma, and valvular heart disease.5[1], 6[2], 7[3] Altered FADS1 activity, reflected in the plasmalogen ratio, connects genetic predisposition to these inflammatory and lipid-related phenotypes.8[4], 9[5]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data