1-(1-enyl-stearoyl)-2-oleoyl-gpe (p-18:0/18:1) to 1-(1-enyl-palmitoyl)-2-arachidonoyl-gpe (p-16:0/20:4)*

Numerator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-oleoyl-gpe (p-18:0/18:1)
Metabolite Accession: GCST90200044
Name: 1-(1-enyl-stearoyl)-2-oleoyl-gpe (p-18:0/18:1)
Hmdb Id: HMDB0011375
Super Pathway: NA
Sub Pathway: NA
Inchikey: XVYPOHCSLJZFED

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-arachidonoyl-gpe (p-16:0/20:4)*
Metabolite Accession: GCST90200048
Name: 1-(1-enyl-palmitoyl)-2-arachidonoyl-gpe (p-16:0/20:4)*
Hmdb Id: HMDB0011352
Super Pathway: NA
Sub Pathway: NA
Inchikey: UUYSKERSKRMYME

Associated Genomic Regions

Region: rs174537

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.121
Position:
61552680
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
7.787
Reference Allele:
G
-log10(P):
-32.614
MAF:
0.337
Beta (Num):
0.037
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.085
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis, Glycerophospholipid metabolism.4[1]

Denominator Metabolite Explanation:

Plasmalogen biosynthesis, Glycerophospholipid metabolism.5[1]

Ratio Explanation:

The ratio reflects FADS enzyme activity, comparing a plasmalogen with oleic acid (18:1) to one with arachidonic acid (20:4), a key FADS product.2[1], 6[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS alters desaturase activity, changing arachidonic acid availability for plasmalogen synthesis.7[1], 8[2] This impacts lipid metabolism and inflammation, contributing to phenotypes like cholelithiasis, hypercholesterolemia, and Type 2 diabetes, which are strongly associated with FADS function.9[3], 10[4], 11[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data