1-(1-enyl-stearoyl)-2-oleoyl-gpe (p-18:0/18:1) to 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)*

Numerator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-oleoyl-gpe (p-18:0/18:1)
Metabolite Accession: GCST90200044
Name: 1-(1-enyl-stearoyl)-2-oleoyl-gpe (p-18:0/18:1)
Hmdb Id: HMDB0011375
Super Pathway: NA
Sub Pathway: NA
Inchikey: XVYPOHCSLJZFED

Denominator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)*
Metabolite Accession: GCST90200058
Name: 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)*
Hmdb Id: HMDB0005779
Super Pathway: NA
Sub Pathway: NA
Inchikey: URPXXNCTXCOATD

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.325
Position:
61569830
SE (Ratio):
0.014
Effect Allele:
T
Z-score (Ratio):
22.653
Reference Allele:
C
-log10(P):
-259.933
MAF:
0.339
Beta (Num):
0.037
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.287
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis, Glycerophospholipid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Plasmalogen biosynthesis, Glycerophospholipid metabolism.6[1]

Ratio Explanation:

This ratio reflects the relative incorporation of oleic acid versus arachidonic acid into plasmalogens, which is influenced by FADS1/FADS2 activity on arachidonic acid synthesis.7[1], 8[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 modulate the synthesis of arachidonic acid, a precursor to inflammatory signaling molecules.9[1] This alteration affects the metabolite ratio and is linked to inflammatory and metabolic phenotypes like asthma, IBD, T2D, and cholelithiasis through its impact on inflammation.10[2], 11[3], 12[4]

Phenotype Driver:

Gene-centric:[FADS1/FADS2]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data