1-(1-enyl-stearoyl)-2-oleoyl-gpe (p-18:0/18:1) to 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*

Numerator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-oleoyl-gpe (p-18:0/18:1)
Metabolite Accession: GCST90200044
Name: 1-(1-enyl-stearoyl)-2-oleoyl-gpe (p-18:0/18:1)
Hmdb Id: HMDB0011375
Super Pathway: NA
Sub Pathway: NA
Inchikey: XVYPOHCSLJZFED

Denominator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Metabolite Accession: GCST90200076
Name: 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Hmdb Id: HMDB0011376
Super Pathway: NA
Sub Pathway: NA
Inchikey: XVXISDREVDGQPX

Associated Genomic Regions

Region: rs174567

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.130
Position:
61593005
SE (Ratio):
0.011
Effect Allele:
G
Z-score (Ratio):
-12.336
Reference Allele:
A
-log10(P):
-78.830
MAF:
0.346
Beta (Num):
0.035
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.166
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis

Denominator Metabolite Explanation:

Plasmalogen biosynthesis

Ratio Explanation:

This ratio reflects FADS enzyme activity, indicating the balance between oleic acid (18:1) and linoleic acid (18:2) incorporated into ethanolamine plasmalogens.4[1], 5[2], 6[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters PUFA synthesis, which impacts lipid profiles and inflammatory responses.1[1], 7[2], 8[3] This dysregulation is linked to phenotypes like pure hypercholesterolemia, cholelithiasis, and inflammatory conditions such as dermatitis and asthma, seen in the associated traits.9[4], 10[5], 11[6]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data