1-stearoyl-2-arachidonoyl-gpe (18:0/20:4) to 1-palmitoyl-2-docosahexaenoyl-gpe (16:0/22:6)*

Numerator Metabolite

Structure of 1-stearoyl-2-arachidonoyl-gpe (18:0/20:4)
Metabolite Accession: GCST90200045
Name: 1-stearoyl-2-arachidonoyl-gpe (18:0/20:4)
Hmdb Id: HMDB0009003
Super Pathway: NA
Sub Pathway: NA
Inchikey: ANRKEHNWXKCXDB

Denominator Metabolite

Structure of 1-palmitoyl-2-docosahexaenoyl-gpe (16:0/22:6)*
Metabolite Accession: GCST90200063
Name: 1-palmitoyl-2-docosahexaenoyl-gpe (16:0/22:6)*
Hmdb Id: HMDB0008946
Super Pathway: NA
Sub Pathway: NA
Inchikey: MPWUZHVZZKSTPV

Associated Genomic Regions

Region: rs174560

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.263
Position:
61581764
SE (Ratio):
0.014
Effect Allele:
C
Z-score (Ratio):
-19.138
Reference Allele:
T
-log10(P):
-186.314
MAF:
0.308
Beta (Num):
-0.233
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.030
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

Region: rs2295602

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Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.114
Position:
11005842
SE (Ratio):
0.013
Effect Allele:
C
Z-score (Ratio):
8.863
Reference Allele:
T
-log10(P):
-41.692
MAF:
0.432
Beta (Num):
0.039
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
-0.074
SE (Den):
0.015
No CNV overlap
rQTL cluster:
112
Reaction Distance:
NA
Closest Genes:
ELOVL2 SYCP2L RP11-637O19.3 SMIM13 ERVFRD-1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, fatty acid biosynthesis.4[1], 5[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, fatty acid biosynthesis.6[1], 7[2]

Ratio Explanation:

The ratio reflects the relative activity of pathways producing arachidonic acid (from omega-6 precursors) versus docosahexaenoic acid (from omega-3 precursors), influenced by FADS1/FADS2 activity.8[1], 3[2], 9[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity, indicated by the metabolite ratio, alters the balance of pro-inflammatory (arachidonic acid-derived) and anti-inflammatory (DHA-derived) eicosanoids, potentially increasing susceptibility to inflammatory conditions like benign colonic neoplasms, cholelithiasis, and asthma, which are observed as associated phenotypes.

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data