1-stearoyl-2-arachidonoyl-gpe (18:0/20:4) to 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)

Numerator Metabolite

Structure of 1-stearoyl-2-arachidonoyl-gpe (18:0/20:4)
Metabolite Accession: GCST90200045
Name: 1-stearoyl-2-arachidonoyl-gpe (18:0/20:4)
Hmdb Id: HMDB0009003
Super Pathway: NA
Sub Pathway: NA
Inchikey: ANRKEHNWXKCXDB

Denominator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Metabolite Accession: GCST90200067
Name: 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Hmdb Id: HMDB0009809
Super Pathway: NA
Sub Pathway: NA
Inchikey: KZVRAFHIKMDULK

Associated Genomic Regions

Region: rs174567

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.431
Position:
61593005
SE (Ratio):
0.022
Effect Allele:
G
Z-score (Ratio):
-19.993
Reference Allele:
A
-log10(P):
-203.083
MAF:
0.346
Beta (Num):
-0.224
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.208
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Arachidonic acid metabolism.3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Linoleic acid metabolism.6[1], 7[2], 8[3]

Ratio Explanation:

The ratio reflects FADS1/FADS2 efficiency in converting phospholipids with linoleic acid (denominator) to those with pro-inflammatory arachidonic acid (numerator).9[1], 10[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1 alters the arachidonic-to-linoleic acid balance, a key process in inflammation.9[1], 10[2] This dysregulation of lipid mediators likely influences susceptibility to associated inflammatory and cardiometabolic phenotypes like hypercholesterolaemia and cholelithiasis.11[3], 12[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data