1-stearoyl-2-arachidonoyl-gpe (18:0/20:4) to 1,2-dilinoleoyl-gpe (18:2/18:2)*

Numerator Metabolite

Structure of 1-stearoyl-2-arachidonoyl-gpe (18:0/20:4)
Metabolite Accession: GCST90200045
Name: 1-stearoyl-2-arachidonoyl-gpe (18:0/20:4)
Hmdb Id: HMDB0009003
Super Pathway: NA
Sub Pathway: NA
Inchikey: ANRKEHNWXKCXDB

Denominator Metabolite

Structure of 1,2-dilinoleoyl-gpe (18:2/18:2)*
Metabolite Accession: GCST90200068
Name: 1,2-dilinoleoyl-gpe (18:2/18:2)*
Hmdb Id: HMDB0009093
Super Pathway: NA
Sub Pathway: NA
Inchikey: SSCDRSKJTAQNNB

Associated Genomic Regions

Region: rs99780

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.452
Position:
61596633
SE (Ratio):
0.022
Effect Allele:
T
Z-score (Ratio):
-20.108
Reference Allele:
C
-log10(P):
-205.389
MAF:
0.346
Beta (Num):
-0.225
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.227
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis

Denominator Metabolite Explanation:

Glycerophospholipid metabolism

Ratio Explanation:

This ratio reflects the conversion of linoleic acid (18:2) containing lipids to arachidonic acid (20:4) containing lipids, a key step regulated by FADS1/FADS2 enzymes.7[1], 9[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in the FADS gene cluster are associated with altered FADS1/FADS2 activity, influencing the ratio of arachidonic acid to linoleic acid-containing lipids, which is linked to variations in cholesterol levels and risk for hypercholesterolemia.10[1], 11[2], 12[3]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data