1-stearoyl-2-arachidonoyl-gpe (18:0/20:4) to dihomo-linolenoylcarnitine (c20:3n3 or 6)*

Numerator Metabolite

Structure of 1-stearoyl-2-arachidonoyl-gpe (18:0/20:4)
Metabolite Accession: GCST90200045
Name: 1-stearoyl-2-arachidonoyl-gpe (18:0/20:4)
Hmdb Id: HMDB0009003
Super Pathway: NA
Sub Pathway: NA
Inchikey: ANRKEHNWXKCXDB

Denominator Metabolite

Metabolite Accession: GCST90200139
Name: dihomo-linolenoylcarnitine (c20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.387
Position:
61581764
SE (Ratio):
0.022
Effect Allele:
C
Z-score (Ratio):
-17.240
Reference Allele:
T
-log10(P):
-151.686
MAF:
0.308
Beta (Num):
-0.233
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.155
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, fatty acid biosynthesis.2[1]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle.

Ratio Explanation:

This ratio reflects FADS1 desaturase activity, comparing its product, arachidonic acid (20:4) in a phospholipid, to its precursor, dihomo-linolenic acid (20:3), as a carnitine.5[1], 6[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters desaturase activity, changing polyunsaturated fatty acid levels. This impacts inflammatory responses and lipid metabolism, plausibly explaining associations with asthma, sinusitis, dermatitis, and disorders of lipoprotein metabolism seen in the phenotype data.7[1], 8[2], 9[3], 10[4], 11[5]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data