1-stearoyl-2-docosahexaenoyl-gpc (18:0/22:6) to 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*

Numerator Metabolite

Structure of 1-stearoyl-2-docosahexaenoyl-gpc (18:0/22:6)
Metabolite Accession: GCST90200046
Name: 1-stearoyl-2-docosahexaenoyl-gpc (18:0/22:6)
Hmdb Id: HMDB0008057
Super Pathway: NA
Sub Pathway: NA
Inchikey: FAUYAENFVCNTAL

Denominator Metabolite

Metabolite Accession: GCST90200051
Name: 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.579
Position:
61569830
SE (Ratio):
0.023
Effect Allele:
T
Z-score (Ratio):
-24.642
Reference Allele:
C
-log10(P):
-307.038
MAF:
0.338
Beta (Num):
-0.247
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.331
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Omega-3 fatty acid synthesis.5[1], 6[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, fatty acid synthesis.7[1], 8[2]

Ratio Explanation:

This ratio reflects the activity of the FADS-regulated PUFA synthesis pathway, comparing a downstream product (containing 22:6) to an upstream precursor (containing 20:3).

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS gene variants alter desaturase activity, impacting the balance of pro- and anti-inflammatory PUFAs.9[1], 10[2] This dysregulation affects lipid and glucose metabolism, contributing to the risk of inflammatory and metabolic phenotypes like cholelithiasis and type 2 diabetes.9[3], 11[4], 12[5], 13[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data