1-(1-enyl-palmitoyl)-2-arachidonoyl-gpe (p-16:0/20:4)* to 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)*

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-arachidonoyl-gpe (p-16:0/20:4)*
Metabolite Accession: GCST90200048
Name: 1-(1-enyl-palmitoyl)-2-arachidonoyl-gpe (p-16:0/20:4)*
Hmdb Id: HMDB0011352
Super Pathway: NA
Sub Pathway: NA
Inchikey: UUYSKERSKRMYME

Denominator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)*
Metabolite Accession: GCST90200058
Name: 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)*
Hmdb Id: HMDB0005779
Super Pathway: NA
Sub Pathway: NA
Inchikey: URPXXNCTXCOATD

Associated Genomic Regions

Region: rs102274

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.205
Position:
61557826
SE (Ratio):
0.010
Effect Allele:
C
Z-score (Ratio):
20.172
Reference Allele:
T
-log10(P):
-206.693
MAF:
0.340
Beta (Num):
-0.083
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.287
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Plasmalogen biosynthesis.5[1], 7[2], 8[3]

Ratio Explanation:

The ratio reflects the balance of two ethanolamine plasmalogens differing in their sn-1 fatty acid (16:0 vs. 18:0), influenced by FADS1-mediated fatty acid metabolism.9[1], 10[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered FADS1 activity impacts the availability of fatty acids for plasmalogen synthesis.9[1], 10[2] This dysregulation of complex lipids is associated with broad metabolic and inflammatory phenotypes like cholelithiasis and Type 2 diabetes, which are strongly linked to FADS1 variants and lipid metabolism.11[3], 12[4], 13[5], 14[6]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data