1-(1-enyl-palmitoyl)-2-arachidonoyl-gpe (p-16:0/20:4)* to 1-(1-enyl-palmitoyl)-2-oleoyl-gpe (p-16:0/18:1)*

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-arachidonoyl-gpe (p-16:0/20:4)*
Metabolite Accession: GCST90200048
Name: 1-(1-enyl-palmitoyl)-2-arachidonoyl-gpe (p-16:0/20:4)*
Hmdb Id: HMDB0011352
Super Pathway: NA
Sub Pathway: NA
Inchikey: UUYSKERSKRMYME

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-oleoyl-gpe (p-16:0/18:1)*
Metabolite Accession: GCST90200061
Name: 1-(1-enyl-palmitoyl)-2-oleoyl-gpe (p-16:0/18:1)*
Hmdb Id: HMDB0011342
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZVVYJAAMWXATNY

Associated Genomic Regions

Region: rs174584

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.140
Position:
61610750
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
-10.325
Reference Allele:
G
-log10(P):
-55.877
MAF:
0.353
Beta (Num):
-0.081
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.059
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FADS3 FEN1 TMEM258

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Plasmalogen biosynthesis4[1], 5[2], 6[3]

Ratio Explanation:

The ratio reflects FADS1/FADS2 activity, where higher activity favors the synthesis of arachidonic acid (20:4) for the numerator over oleic acid (18:1) incorporation.1[1], 7[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS1/FADS2 gene variants influence the conversion efficiency of fatty acids, affecting the balance of plasmalogens.1[1], 8[2], 9[3] This altered lipid profile is associated with cholesterol levels and inflammatory conditions like asthma and dermatitis, linking genetic predisposition to metabolic and disease phenotypes.10[4], 11[5], 12[6], 13[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data