1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)* to 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)

Numerator Metabolite

Metabolite Accession: GCST90200051
Name: 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)
Metabolite Accession: GCST90199649
Name: 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)
Hmdb Id: HMDB0009815
Super Pathway: NA
Sub Pathway: NA
Inchikey: KRTOMQDUKGRFDJ

Associated Genomic Regions

Region: rs174548

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.595
Position:
61571348
SE (Ratio):
0.019
Effect Allele:
G
Z-score (Ratio):
31.771
Reference Allele:
C
-log10(P):
-508.387
MAF:
0.310
Beta (Num):
0.332
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.263
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Phosphatidylcholine biosynthesis

Denominator Metabolite Explanation:

Phospholipid Metabolism, Phosphatidylinositol signaling system

Ratio Explanation:

This ratio may reflect the activity of FADS1, which is involved in the synthesis of arachidonic acid (20:4), the denominator, from its precursors.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1 activity, reflected by the ratio, is associated with altered inflammatory and immune responses, potentially contributing to the risk of asthma and hypercholesterolemia.3[1], 4[2], 5[3], 6[4], 7[5] The FADS1 gene is linked to these phenotypes through its role in producing inflammatory lipid mediators.2[6], 8[7], 9[8]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data