1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)* to 1,2-dipalmitoyl-gpc (16:0/16:0)

Numerator Metabolite

Metabolite Accession: GCST90200051
Name: 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1,2-dipalmitoyl-gpc (16:0/16:0)
Metabolite Accession: GCST90199660
Name: 1,2-dipalmitoyl-gpc (16:0/16:0)
Hmdb Id: HMDB0000564
Super Pathway: NA
Sub Pathway: NA
Inchikey: KILNVBDSWZSGLL

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.545
Position:
61557803
SE (Ratio):
0.020
Effect Allele:
C
Z-score (Ratio):
26.661
Reference Allele:
T
-log10(P):
-358.917
MAF:
0.347
Beta (Num):
0.324
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.221
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Phospholipid and PUFA metabolism.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Phospholipid and Saturated Fatty Acid metabolism.7[1], 8[2], 9[3]

Ratio Explanation:

This ratio reflects FADS1 desaturase activity, comparing a phospholipid with a PUFA (20:3) substrate of FADS1 against a fully saturated phospholipid species.10[1], 4[2], 11[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1 alters its desaturase activity, impacting PUFA levels. This change in the lipid profile is causally linked to disorders of lipoprotein metabolism, including pure hypercholesterolaemia, and inflammatory diseases like asthma and IBD which are strongly associated with lipid mediators.1[1], 4[2], 12[3]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data