1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)* to 1-arachidonylglycerol (20:4)

Numerator Metabolite

Metabolite Accession: GCST90200051
Name: 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-arachidonylglycerol (20:4)
Metabolite Accession: GCST90199770
Name: 1-arachidonylglycerol (20:4)
Hmdb Id: HMDB0011578
Super Pathway: NA
Sub Pathway: NA
Inchikey: DCPCOKIYJYGMDN

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.598
Position:
61588305
SE (Ratio):
0.021
Effect Allele:
G
Z-score (Ratio):
27.902
Reference Allele:
A
-log10(P):
-392.820
MAF:
0.345
Beta (Num):
0.327
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.271
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, fatty acid biosynthesis.1[1], 4[2]

Denominator Metabolite Explanation:

Endocannabinoid signaling, glycerolipid metabolism.5[1], 6[2]

Ratio Explanation:

This ratio reflects the activity of FADS1, which synthesizes the precursor of the denominator (arachidonic acid), influencing the balance of polyunsaturated fatty acids.1[1], 7[2], 8[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity alters the balance of omega-3 and omega-6 fatty acids, which is linked to dyslipidemia, including changes in cholesterol levels and an increased risk for cholelithiasis and type 2 diabetes.9[1], 10[2], 11[3], 12[4], 13[5], 14[6]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data