1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)* to 1-arachidonoyl-gpc (20:4n6)*

Numerator Metabolite

Metabolite Accession: GCST90200051
Name: 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-arachidonoyl-gpc (20:4n6)*
Metabolite Accession: GCST90199788
Name: 1-arachidonoyl-gpc (20:4n6)*
Hmdb Id: HMDB0010395
Super Pathway: NA
Sub Pathway: NA
Inchikey: LAXQYRRMGGEGOH

Associated Genomic Regions

Region: rs174528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.815
Position:
61543499
SE (Ratio):
0.021
Effect Allele:
C
Z-score (Ratio):
38.366
Reference Allele:
T
-log10(P):
-739.834
MAF:
0.371
Beta (Num):
0.305
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.510
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
MYRF TMEM258 FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism

Denominator Metabolite Explanation:

Glycerophospholipid metabolism

Ratio Explanation:

The ratio of 1-palmitoyl-2-dihomo-linolenoyl-gpc to 1-arachidonoyl-gpc reflects the enzymatic efficiency of FADS1 in converting precursor to product in the omega-6 pathway.

Ratio Evidence:

canonical reaction catalyzed by the enzyme

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1 alter enzyme activity, impacting the balance of polyunsaturated fatty acids.3[1], 4[2], 5[3] This dysregulation of lipid mediators is linked to hypercholesterolemia and other lipoprotein metabolism disorders, increasing the risk for associated cardiovascular phenotypes.6[4], 7[5], 8[6], 9[7]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data