1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)* to 1-arachidonoyl-gpe (20:4n6)*

Numerator Metabolite

Metabolite Accession: GCST90200051
Name: 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-arachidonoyl-gpe (20:4n6)*
Metabolite Accession: GCST90199791
Name: 1-arachidonoyl-gpe (20:4n6)*
Hmdb Id: HMDB0011517
Super Pathway: NA
Sub Pathway: NA
Inchikey: ROPRRXYVXLDXQO

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.697
Position:
61557803
SE (Ratio):
0.019
Effect Allele:
C
Z-score (Ratio):
35.836
Reference Allele:
T
-log10(P):
-645.929
MAF:
0.347
Beta (Num):
0.324
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.372
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, fatty acid biosynthesis.

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, fatty acid biosynthesis.

Ratio Explanation:

The ratio reflects FADS1 activity, where lower activity leads to a higher proportion of the precursor 1-palmitoyl-2-dihomo-linolenoyl-gpc relative to the product-associated 1-arachidonoyl-gpe.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1 activity alters the balance of pro-inflammatory and anti-inflammatory lipid mediators, contributing to chronic inflammatory conditions like asthma, inflammatory bowel disease, and dermatitis, and also impacting lipid metabolism leading to hypercholesterolemia.2[1], 3[2], 4[3], 5[4], 6[5]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data