1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)* to 1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)*

Numerator Metabolite

Metabolite Accession: GCST90200051
Name: 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)*
Metabolite Accession: GCST90200054
Name: 1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)*
Hmdb Id: HMDB0005323
Super Pathway: NA
Sub Pathway: NA
Inchikey: DRIVXEVMDWCWLI

Associated Genomic Regions

Region: rs99780

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.465
Position:
61596633
SE (Ratio):
0.019
Effect Allele:
T
Z-score (Ratio):
24.488
Reference Allele:
C
-log10(P):
-303.264
MAF:
0.347
Beta (Num):
0.325
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.140
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Phospholipid metabolism6[1], 7[2], 8[3], 9[4]

Denominator Metabolite Explanation:

Phospholipid metabolism10[1], 11[2], 12[3]

Ratio Explanation:

This ratio reflects the activity of the FADS1 enzyme; a lower ratio indicates decreased enzyme efficiency in converting the numerator into the denominator's precursor.13[1], 14[2], 15[3]

Ratio Evidence:

canonical reaction catalyzed by the enzyme

Gene Ratio Phenotype Relationship:

FADS1 variants impact delta-5 desaturase activity, altering the balance of pro-inflammatory (arachidonic acid-derived) and anti-inflammatory lipids, which is linked to hypercholesterolemia and cardiovascular risk.16[1], 17[2], 18[3], 14[4], 19[5], 15[6]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data