1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)* to linoleoyl-arachidonoyl-glycerol (18:2/20:4) [1]*

Numerator Metabolite

Metabolite Accession: GCST90200051
Name: 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of linoleoyl-arachidonoyl-glycerol (18:2/20:4) [1]*
Metabolite Accession: GCST90200103
Name: linoleoyl-arachidonoyl-glycerol (18:2/20:4) [1]*
Hmdb Id: HMDB0007257
Super Pathway: NA
Sub Pathway: NA
Inchikey: KRECEGQUDDMNAQ

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.644
Position:
61588305
SE (Ratio):
0.021
Effect Allele:
G
Z-score (Ratio):
30.931
Reference Allele:
A
-log10(P):
-482.015
MAF:
0.345
Beta (Num):
0.327
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.316
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Fatty acid biosynthesis.8[1], 9[2], 10[3], 11[4], 12[5], 13[6]

Denominator Metabolite Explanation:

Glycerolipid metabolism, Phospholipid biosynthesis.14[1], 15[2]

Ratio Explanation:

This ratio reflects the activity of FADS1/FADS2 enzymes, converting shorter-chain fatty acids to longer-chain, more unsaturated fatty acids like arachidonic acid, a key inflammatory mediator.3[1], 16[2], 17[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity is associated with lower levels of pro-inflammatory arachidonic acid-derived mediators.3[1], 17[2] This may lead to a less inflammatory environment, potentially decreasing the risk or severity of nasal polyps.

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data