1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)* to linoleoyl-arachidonoyl-glycerol (18:2/20:4) [2]*

Numerator Metabolite

Metabolite Accession: GCST90200051
Name: 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of linoleoyl-arachidonoyl-glycerol (18:2/20:4) [2]*
Metabolite Accession: GCST90200109
Name: linoleoyl-arachidonoyl-glycerol (18:2/20:4) [2]*
Hmdb Id: HMDB0007257
Super Pathway: NA
Sub Pathway: NA
Inchikey: KRECEGQUDDMNAQ

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.654
Position:
61588305
SE (Ratio):
0.022
Effect Allele:
G
Z-score (Ratio):
30.381
Reference Allele:
A
-log10(P):
-465.155
MAF:
0.345
Beta (Num):
0.327
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.327
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.4[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Diacylglycerol metabolism.5[1]

Ratio Explanation:

The ratio reflects the conversion of fatty acids by FADS1, where the numerator is a precursor to the denominator's arachidonoyl component, indicating desaturase activity.4[1]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in the FADS1/FADS2 gene cluster alter desaturase activity, affecting the balance of polyunsaturated fatty acids.1[1], 6[2] This dysregulation is linked to inflammatory conditions like seborrhoeic dermatitis and nasal polyps, likely through modulation of inflammatory mediators derived from these fatty acids.7[3], 8[4], 9[5], 10[6]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data