1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)* to sphingomyelin (d18:2/21:0, d16:2/23:0)*

Numerator Metabolite

Metabolite Accession: GCST90200051
Name: 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200129
Name: sphingomyelin (d18:2/21:0, d16:2/23:0)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174548

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.429
Position:
61571348
SE (Ratio):
0.019
Effect Allele:
G
Z-score (Ratio):
22.041
Reference Allele:
C
-log10(P):
-246.228
MAF:
0.310
Beta (Num):
0.332
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.098
SE (Den):
0.014
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism

Denominator Metabolite Explanation:

Sphingolipid metabolism.6[1], 7[2]

Ratio Explanation:

The ratio of 1-palmitoyl-2-dihomo-linolenoyl-gpc to sphingomyelin reflects the balance between glycerophospholipid and sphingolipid pathways, influenced by FADS1/FADS2-mediated synthesis of the numerator's fatty acid component.2[1], 1[2], 8[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in the FADS cluster alter the activity of desaturase enzymes, affecting the balance of polyunsaturated fatty acids.9[1], 10[2], 11[3], 12[4] This modified lipid profile, reflected in the metabolite ratio, is associated with an increased risk for inflammatory conditions like seborrhoeic dermatitis.13[5]

Phenotype Driver:

Gene-centric:FADS1, FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data