1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)* to arachidonoylcarnitine (c20:4)

Numerator Metabolite

Metabolite Accession: GCST90200051
Name: 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of arachidonoylcarnitine (c20:4)
Metabolite Accession: GCST90200150
Name: arachidonoylcarnitine (c20:4)
Hmdb Id: HMDB0006455
Super Pathway: NA
Sub Pathway: NA
Inchikey: RBFQHRALHSUPIA

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.598
Position:
61569830
SE (Ratio):
0.022
Effect Allele:
T
Z-score (Ratio):
27.500
Reference Allele:
C
-log10(P):
-381.654
MAF:
0.340
Beta (Num):
0.331
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.266
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Phosphatidylcholine metabolism, Glycerophospholipid metabolism.6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, Carnitine shuttle.9[1], 10[2], 11[3], 12[4]

Ratio Explanation:

This ratio reflects the activity of FADS1/FADS2, where lower activity leads to higher levels of the precursor (numerator) and lower levels of the product (denominator).13[1], 5[2], 14[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity, indicated by an increased ratio, is associated with altered lipid profiles and an increased risk for inflammatory and metabolic conditions like type 2 diabetes, hypercholesterolemia, and cholelithiasis.15[1], 16[2], 17[3], 18[4], 19[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data