1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)* to 1-palmitoyl-2-arachidonoyl-gpc (16:0/20:4n6)

Numerator Metabolite

Metabolite Accession: GCST90200051
Name: 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-palmitoyl-2-arachidonoyl-gpc (16:0/20:4n6)
Metabolite Accession: GCST90200692
Name: 1-palmitoyl-2-arachidonoyl-gpc (16:0/20:4n6)
Hmdb Id: HMDB0007982
Super Pathway: NA
Sub Pathway: NA
Inchikey: IIZPXYDJLKNOIY

Associated Genomic Regions

Region: rs174528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.860
Position:
61543499
SE (Ratio):
0.019
Effect Allele:
C
Z-score (Ratio):
45.900
Reference Allele:
T
-log10(P):
-1057.443
MAF:
0.371
Beta (Num):
0.305
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.555
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
MYRF TMEM258 FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Omega-3/Omega-6 fatty acid metabolism

Denominator Metabolite Explanation:

Omega-6 fatty acid metabolism

Ratio Explanation:

This ratio reflects the enzymatic efficiency of delta-5 desaturase (FADS1), comparing its substrate (dihomo-linolenoyl-GPC) to its product (arachidonoyl-GPC).4[1], 5[2], 6[3]

Ratio Evidence:

canonical reaction catalyzed by the enzyme

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter polyunsaturated fatty acid (PUFA) metabolism, which is reflected in the ratio.7[1], 8[2], 9[3] Mendelian randomization causally links this altered ratio to dyslipidemia and pure hypercholesterolemia, likely through the known effects of PUFAs on cholesterol and lipoprotein metabolism.10[4], 11[5], 12[6], 13[7]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data